Quick facts
Loop diuretics, alcohol, and a poor diet cause low magnesium
- Hypomagnesemia usually comes from too little magnesium in the diet or from loop diuretics, which excrete it. Alcohol use disorder and long-term proton pump inhibitor use are other causes.[2]
- Signs include nausea, vomiting, lethargy, weakness, leg cramps, tremor, dysrhythmias, and tetany, which is linked to the low calcium that can come with low magnesium.[2]
- Hypomagnesemia, like hypokalemia, can increase the risk of digoxin toxicity, and loop diuretics such as furosemide cause magnesium losses along with potassium.[4]
High magnesium usually comes from kidney failure or extra magnesium
- Hypermagnesemia usually comes from kidney failure, too much magnesium replacement, or magnesium-containing laxatives or antacids.[2][5]
- Signs include bradycardia, a weak and thready pulse, lethargy, hyporeflexia, and muscle weakness, and it can progress to cardiac arrest.[2]
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Practice question
An adult patient with alcohol use disorder who takes furosemide has a serum magnesium of 1.2 mg/dL. The laboratory reference range is 1.6 to 2.6 mg/dL. Which assessment finding should the nurse expect?
- A. Hyporeflexia and a heart rate of 52 beats per minute
- B. Cramping legs and muscle tetany
- C. Constipation and increased thirst
- D. A weak, thready pulse
Show the answer and why
Correct answer: B. Cramping legs and muscle tetany
- A. Incorrect. Hyporeflexia and bradycardia are signs of high magnesium. This patient's magnesium is low.
- B. Correct. 1.2 mg/dL is below 1.6. Leg cramps and tetany are signs of hypomagnesemia (tremor can come with high or low magnesium), and both furosemide and alcohol use disorder are common causes.
- C. Incorrect. Constipation and increased thirst are signs of high calcium, not low magnesium.
- D. Incorrect. A weak and thready pulse is listed with high magnesium, along with bradycardia and hyporeflexia.
Sources for this question: [1][2]
Memory hook: High magnesium slows the pulse and the reflexes; low magnesium cramps the legs and can cause dysrhythmias.